The Sagebrush Conservation Design (SCD) is a tool to identify intact sagebrush areas and address the largest threats to the ecosystem. The SCD focuses on first protecting intact and functioning sagebrush ecosystems, called Core Sagebrush Areas, then works outward toward more degraded areas (i.e., “Defend the Core”). The premise behind the Defend the Core approach is simple: focus resources first on preventative actions that retain ecosystem services in Core Sagebrush Areas because they are more cost-effective and more likely to be successful. The November 2024 special issue of Rangeland Ecology and Management is dedicated to applying the SCD to improve conservation outcomes across the sagebrush biome in the face of pervasive ecosystem threats. This special issue provides new science and real-world examples of how we can implement the SCD to save a biome. The overarching themes are: 1) Business-As-Usual Won't Save the Sagebrush Sea, 2) Better Spatial Targeting Can Improve Outcomes, 3) Conservation Planning is Needed to Develop Realistic Business Plans, 4) Targeted Ecosystem Management: Monitoring Shows Managing for Sagebrush Ecological Integrity is Working, 5) Maintaining Sagebrush Ecological Integrity is Ecologically Relevant, and 6) There is Only Hope if We Manage Change. The collective articles show that there is no shared plan to save the biome, yet a business plan for the biome could ensure realistic goals. The sagebrush biome still has vast expanses of open spaces with high ecological integrity at a scale that is rare in other ecological systems within the lower 48 states. If we focus on the common ground of the main drivers of ecosystem change, implementing the SCD and Defending the Core are viable strategies to help save a biome.